West nile virus ns2b/ns3 protease as an antiviral target

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Eur J Med Chem , , 31 Aug Cited by: 5 articles PMID: ChemMedChem , 15 15 , 30 Jun Curr Med Chem , 15 27 , 01 Jan Cited by: 44 articles PMID: Antiviral Res , , 02 Apr Cited by: 80 articles PMID: Contact us. Europe PMC requires Javascript to function effectively. Recent Activity. Search life-sciences literature Over 39 million articles, preprints and more Search Advanced search.

Search articles by 'Aleksandra Milewska'. Milewska A 2 ,. Oleksyszyn J 1. Affiliations 3 authors 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Free full text. J Enzyme Inhib Med Chem.

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This article has been cited by other articles in PMC. Introduction The West Nile virus WNV belongs to the flavivirus genus Flaviviridae family and is a mosquito-borne human pathogen of global occurrence. Open in a separate window. Figure 1. Figure 2. Figure 3. Figure 4. Results and discussion Inhibitor P 1 position screening Compounds presented in this study are categorised into three groups: I compounds 6 — 11 are simple diphenyl phosphonate analogues of lysine, arginine, glutamine, ornithine, homoarginine, and thioarginine; II compounds 12 — 23 are aromatic analogues bearing a basic moiety, and III derivatives of diphenylphosphonatec phenylglycine 24 — 27 with different heterocyclic substituents.

Table 1. Bold values indicate the most active compounds. Influence of peptide chain elongation The structure of the most active inhibitors identified in the initial screening step was elongated with a P2 Arg and P3 Lys. Table 2. Bold value indicates the most active compound. Acknowledgements The authors would like to thank Dr.

Disclosure statement No potential conflict of interest was reported by the authors. References 1. A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop Med Hyg ; s1—20 — Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science ; —7. Evolution of new genotype of West Nile virus in North America. Emerging Infect Dis ; 17 — Available from: www.

Sejvar JJ. West Nile virus: an historical overview. Ochsner J ; 5 :6— West Nile virus: biology, transmission, and human infection. Clin Microbiol Rev ; 25 — Holbrook MR. Historical perspectives on flavivirus research. Our website will not work properly.

Please update to a newer version or download a new web browser, such as Chrome or Firefox. Asymmetric Unit. Macromolecule Content Total Structure Weight: This is version 1. Cite this article as: Chappell J. Close About this journal. Current Bioactive Compounds. Current Topics in Medicinal Chemistry.

Medicinal Chemistry. Mini-Reviews in Medicinal Chemistry. Current Drug Research Reviews. Anti-Cancer Agents in Medicinal Chemistry. Anti-Infective Agents. View More. Since her freshman year, Nguyen, a biochemistry major who is graduating in May, has worked in the lab of Nicholas T. Salzameda, associate professor of chemistry and biochemistry. The researchers are seeking treatments since there is no vaccine or medications available for the mosquito-borne disease. In the ongoing study, the faculty-student research team is studying a viral protein for the West Nile virus, known as the NS2B-NS3 protease, which is responsible for producing viral particles for replication and is a promising therapeutic target in stopping infection, Nguyen said.