Randomised controlled trial evaluating

Dong, E. Dis 20 , — Sanders, J. JAMA , — Kaddoura, M. Perricone, C. Savarino, A. Dis 3 , — Tang, W. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease open label, randomised controlled trial. BMJ , m Article Google Scholar. Boulware, D. A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid Cavalcanti, A. Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid Horby, P. Effect of hydroxychloroquine in hospitalized patients with covid Berlin, D.

Severe Covid Alhazzani, W. Intensive Care Med. Imagem, C. Borba, M. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection: A randomized clinical trial.

JAMA Netw. Open 3 , e Article PubMed Google Scholar. Developing the World Health Organization disability assessment schedule 2.

World Health Organ. Dexamethasone in hospitalized patients with Covid Preliminary Report. Liang, W. Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID JAMA Intern.

Beigel, J. Remdesivir for the treatment of Covid Final report. Furtado, R. Lancet London, England , — Chen, Z. Abd-Elsalam, S. Geleris, J. Observational study of hydroxychloroquine in hospitalized patients with Covid Hoffmann, M. Nature , — Mahmoudi, J. Schrezenmeier, E. Mechanisms of action of hydroxychloroquine and chloroquine: Implications for rheumatology. Desai, A. Marshall, J. Dis 20 , e—e Download references. We thank all participating centers for the support and interventions in our study during this challenging period for everyone, especially Hospital Santa Casa de Misericordia de Curitiba—Dr.

Danilo Bastos Pompemayer, Dra. Ana Flavia Kalled, and Dr. Mariana Bruinje Cosentino and Dr. Flavia Castanho Hubert and Dra. Rafael Alexandre de Oliveira Deucher and Dr. Karen Fernandes de Moura. You can also search for this author in PubMed Google Scholar. All authors have approved the submitted version and agreed to be personally accountable for their own contributions and to ensure that questions related to the accuracy or integrity of any part of the work, even those in which the author was not personally involved, are appropriately investigated and resolved and that the resolution is documented in the literature.

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Reprints and Permissions. Sci Rep 11, Download citation. Received : 11 December Accepted : 13 April Published : 27 April Anyone you share the following link with will be able to read this content:.

Study details and data on safety and efficacy were abstracted from included trials. Results were visualised in an evidence map. Risk of bias: Only RCTs were included in this review to reduce the risk of selection bias in the evaluation of genetic therapy safety and efficacy. Included studies: We identified RCTs evaluating genetic therapies for a variety of clinical conditions. Synthesis of results: On average, samples included participants range: , and were followed for 15 months range: Improvement was reported in trials treating cancer, cardiovascular, ocular and muscular diseases.

However, only 19 trials reported symptom improvement for at least 1 year. Login Login and comment as BetterEvaluation member or simply fill out the fields below. Excerpt "A randomized controlled trial RCT is a way of doing impact evaluation in which the population receiving the programme or policy intervention is chosen at random from the eligible population, and a control group is also chosen at random from the same eligible population. How to conduct a randomized controlled trial Ethical issues and practical limitations Which other methods work well with this one?

Presentation of results and analysis Example of good practices Examples of challenges See more in the Impact Evaluation Series here. No votes yet. Randomised Controlled Trial , Impact evaluation.